Topoisomerase Inhibitor [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Off label use | 9,271 | 4 | 2,056 | 2,898 | 973 |
| Febrile neutropenia | 8,416 | 4 | 1,166 | 4,787 | 1,395 |
| Neutropenia | 6,725 | 4 | 1,040 | 2,158 | 841 |
| Disease progression | 6,174 | 4 | 1,851 | 865 | 164 |
| Diarrhoea | 6,025 | 4 | 929 | 2,904 | 463 |
| Drug ineffective | 5,329 | 4 | 1,646 | 1,452 | 605 |
| Thrombocytopenia | 4,762 | 4 | 863 | 1,658 | 627 |
| Nausea | 4,415 | 4 | 488 | 2,062 | 301 |
| Anaemia | 4,174 | 4 | 631 | 1,790 | 490 |
| Pyrexia | 4,064 | 4 | 598 | 2,729 | 461 |
| Product use in unapproved indication | 3,883 | 4 | 788 | 835 | 352 |
| Vomiting | 3,736 | 4 | 513 | 2,066 | 362 |
| Death | 3,179 | 4 | 3,173 | 417 | 96 |
| Sepsis | 3,062 | 4 | 1,478 | 1,426 | 558 |
| Malignant neoplasm progression | 2,885 | 4 | 1,059 | 511 | 119 |
| Fatigue | 2,824 | 4 | 410 | 1,159 | 159 |
| Pancytopenia | 2,711 | 4 | 565 | 1,354 | 443 |
| Myelosuppression | 2,388 | 4 | 166 | 1,081 | 305 |
| Mucosal inflammation | 2,346 | 4 | 383 | 1,024 | 308 |
| Pneumonia | 2,320 | 4 | 956 | 1,247 | 339 |
| Neuropathy peripheral | 2,081 | 4 | 171 | 381 | 72 |
| Infection | 2,000 | 4 | 729 | 493 | 130 |
| Asthenia | 2,000 | 4 | 294 | 1,005 | 133 |
| Decreased appetite | 1,896 | 4 | 304 | 972 | 126 |
| Dyspnoea | 1,848 | 4 | 329 | 1,026 | 233 |
| Leukopenia | 1,784 | 4 | 273 | 579 | 162 |
| Acute kidney injury | 1,738 | 4 | 414 | 1,093 | 260 |
| Abdominal pain | 1,697 | 4 | 242 | 1,015 | 111 |
| Neoplasm progression | 1,692 | 4 | 502 | 345 | 101 |
| Septic shock | 1,647 | 4 | 818 | 939 | 426 |