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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Topoisomerase Inhibitors [MoA]: Side Effects & Safety Data for 8 Drugs

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Topoisomerase Inhibitors [MoA] includes 8 drugs with a combined 202,189 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.

8
Drugs in Class
202,189
Combined Reports

All Topoisomerase Inhibitors [MoA] Drugs Ranked by Reports

Drug Brand Name Reports Deaths Hosp. Death Rate
DOXORUBICIN Doxorubicin Hydrochloride 82,754 15,653 28,630 18.9%
ETOPOSIDE Avopef 52,603 11,780 17,699 22.4%
IRINOTECAN Irinotecan Hydrochloride 27,965 4,530 10,384 16.2%
EPIRUBICIN Ellence 16,274 2,212 5,603 13.6%
DAUNORUBICIN Daunorubicin Hydrochloride 9,852 2,263 4,248 23.0%
IDARUBICIN Idamycin PFS 5,038 1,260 1,856 25.0%
MITOXANTRONE mitoXANTRONE 4,166 995 1,556 23.9%
TOPOTECAN HYCAMTIN 3,537 773 1,213 21.9%

Common Side Effects in Topoisomerase Inhibitors [MoA] Drugs

Side EffectReportsDeaths
Febrile neutropenia 20,138 2,615
Off label use 18,583 4,109
Neutropenia 14,556 2,248
Disease progression 13,068 3,490
Drug ineffective 10,956 3,323
Diarrhoea 9,498 1,486
Thrombocytopenia 9,481 1,727
Pyrexia 9,448 1,320
Nausea 8,887 888
Anaemia 8,661 1,289
View detailed side effects for this class → Compare drugs in this class →