Topoisomerase Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Febrile neutropenia | 20,138 | 8 | 2,615 | 11,879 | 3,037 |
| Off label use | 18,583 | 8 | 4,109 | 5,709 | 1,848 |
| Neutropenia | 14,556 | 8 | 2,248 | 5,003 | 2,057 |
| Disease progression | 13,068 | 8 | 3,490 | 1,837 | 365 |
| Drug ineffective | 10,956 | 8 | 3,323 | 2,897 | 1,206 |
| Diarrhoea | 9,498 | 8 | 1,486 | 4,697 | 770 |
| Thrombocytopenia | 9,481 | 8 | 1,727 | 3,404 | 1,316 |
| Pyrexia | 9,448 | 8 | 1,320 | 6,311 | 1,075 |
| Nausea | 8,887 | 8 | 888 | 4,087 | 629 |
| Anaemia | 8,661 | 8 | 1,289 | 3,702 | 1,095 |
| Product use in unapproved indication | 7,981 | 8 | 1,770 | 1,990 | 761 |
| Vomiting | 7,304 | 8 | 949 | 3,878 | 680 |
| Death | 6,850 | 8 | 6,842 | 811 | 222 |
| Sepsis | 6,824 | 8 | 3,408 | 3,192 | 1,200 |
| Pneumonia | 5,779 | 8 | 2,170 | 3,182 | 867 |
| Pancytopenia | 5,777 | 8 | 1,222 | 2,827 | 856 |
| Fatigue | 5,746 | 8 | 752 | 2,394 | 368 |
| Malignant neoplasm progression | 5,688 | 8 | 1,805 | 931 | 277 |
| Myelosuppression | 4,982 | 8 | 353 | 2,268 | 621 |
| Mucosal inflammation | 4,899 | 8 | 747 | 2,125 | 580 |
| Neuropathy peripheral | 4,528 | 8 | 405 | 857 | 168 |
| Infection | 4,516 | 8 | 1,708 | 1,296 | 338 |
| Asthenia | 4,261 | 8 | 555 | 2,182 | 329 |
| Dyspnoea | 4,216 | 8 | 694 | 2,411 | 485 |
| Leukopenia | 4,131 | 8 | 590 | 1,303 | 430 |
| Septic shock | 3,846 | 8 | 2,055 | 2,208 | 1,061 |
| White blood cell count decreased | 3,555 | 8 | 328 | 1,688 | 366 |
| Acute myeloid leukaemia | 3,535 | 8 | 1,671 | 884 | 573 |
| Acute kidney injury | 3,520 | 8 | 876 | 2,209 | 576 |
| Decreased appetite | 3,473 | 8 | 483 | 1,796 | 280 |