Does ALLOPURINOL Cause Cholestasis? 186 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 186 reports of Cholestasis have been filed in association with ALLOPURINOL (Allopurinol). This represents 1.0% of all adverse event reports for ALLOPURINOL.
186
Reports of Cholestasis with ALLOPURINOL
1.0%
of all ALLOPURINOL reports
3
Deaths
150
Hospitalizations
How Dangerous Is Cholestasis From ALLOPURINOL?
Of the 186 reports, 3 (1.6%) resulted in death, 150 (80.6%) required hospitalization, and 9 (4.8%) were considered life-threatening.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ALLOPURINOL. However, 186 reports have been filed with the FAERS database.
What Other Side Effects Does ALLOPURINOL Cause?
Drug reaction with eosinophilia and systemic symptoms (2,943)
Acute kidney injury (1,583)
Rash (1,103)
Off label use (921)
Pyrexia (913)
Dyspnoea (905)
Toxic epidermal necrolysis (858)
Pruritus (836)
Diarrhoea (819)
Drug ineffective (780)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which ALLOPURINOL Alternatives Have Lower Cholestasis Risk?
ALLOPURINOL vs ALMOTRIPTAN
ALLOPURINOL vs ALMOTRIPTAN MALATE
ALLOPURINOL vs ALOE VERA LEAF
ALLOPURINOL vs ALOGLIPTIN
ALLOPURINOL vs ALOGLIPTIN\METFORMIN