Does APREMILAST Cause Skin necrosis? 155 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 155 reports of Skin necrosis have been filed in association with APREMILAST (Otezla). This represents 0.1% of all adverse event reports for APREMILAST.
155
Reports of Skin necrosis with APREMILAST
0.1%
of all APREMILAST reports
0
Deaths
150
Hospitalizations
How Dangerous Is Skin necrosis From APREMILAST?
Of the 155 reports, 150 (96.8%) required hospitalization, and 2 (1.3%) were considered life-threatening.
Is Skin necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for APREMILAST. However, 155 reports have been filed with the FAERS database.
What Other Side Effects Does APREMILAST Cause?
Diarrhoea (23,752)
Nausea (21,352)
Psoriasis (19,255)
Headache (17,024)
Drug ineffective (14,121)
Abdominal discomfort (7,653)
Psoriatic arthropathy (7,035)
Vomiting (5,959)
Rash (5,883)
Pain (5,676)
What Other Drugs Cause Skin necrosis?
METHOTREXATE (620)
ADALIMUMAB (576)
RITUXIMAB (565)
TOCILIZUMAB (530)
ABATACEPT (528)
LEFLUNOMIDE (525)
ETANERCEPT (493)
INFLIXIMAB (491)
HYDROXYCHLOROQUINE (482)
CODEINE (481)
Which APREMILAST Alternatives Have Lower Skin necrosis Risk?
APREMILAST vs APREPITANT
APREMILAST vs APROTININ
APREMILAST vs ARANESP
APREMILAST vs ARAVA
APREMILAST vs AREDIA