Does METHOTREXATE Cause Skin necrosis? 620 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 620 reports of Skin necrosis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
620
Reports of Skin necrosis with METHOTREXATE
0.2%
of all METHOTREXATE reports
9
Deaths
557
Hospitalizations
How Dangerous Is Skin necrosis From METHOTREXATE?
Of the 620 reports, 9 (1.5%) resulted in death, 557 (89.8%) required hospitalization, and 38 (6.1%) were considered life-threatening.
Is Skin necrosis Listed in the Official Label?
Yes, Skin necrosis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Skin necrosis?
ADALIMUMAB (576)
RITUXIMAB (565)
TOCILIZUMAB (530)
ABATACEPT (528)
LEFLUNOMIDE (525)
ETANERCEPT (493)
INFLIXIMAB (491)
HYDROXYCHLOROQUINE (482)
CODEINE (481)
SULFASALAZINE (475)
Which METHOTREXATE Alternatives Have Lower Skin necrosis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA