Skin necrosis: Which Medications Cause It? (3,417 Reports Across 292 Drugs)
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Skin necrosis has been reported as an adverse event with 292 different drugs in the FDA's FAERS database, with 3,417 total reports. 340 of these reports resulted in death.The drugs most commonly associated with Skin necrosis are METHOTREXATE, ADALIMUMAB, and RITUXIMAB.
3,417
Total Reports
292
Drugs Involved
340
Deaths
1,917
Hospitalizations
55.9 yrs
Average Patient Age
61.0% / 39.0%
Female / Male
Which Drugs Cause Skin necrosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 620 | 0.2% | 9 | 557 | 38 |
| ADALIMUMAB | 576 | 0.1% | 6 | 522 | 23 |
| RITUXIMAB | 565 | 0.3% | 6 | 525 | 22 |
| TOCILIZUMAB | 530 | 0.5% | 5 | 502 | 26 |
| ABATACEPT | 528 | 0.5% | 0 | 510 | 22 |
| LEFLUNOMIDE | 525 | 0.9% | 6 | 502 | 21 |
| ETANERCEPT | 493 | 0.1% | 0 | 471 | 22 |
| INFLIXIMAB | 491 | 0.4% | 0 | 477 | 20 |
| HYDROXYCHLOROQUINE | 482 | 0.7% | 1 | 467 | 22 |
| CODEINE | 481 | 2.2% | 0 | 469 | 19 |
| SULFASALAZINE | 475 | 1.2% | 0 | 462 | 20 |
| ALENDRONATE | 442 | 1.6% | 0 | 430 | 18 |
| GOLD THIOMALATE | 351 | 7.9% | 0 | 347 | 19 |
| CYCLOSPORINE | 261 | 0.4% | 31 | 242 | 25 |
| CERTOLIZUMAB PEGOL | 248 | 0.3% | 1 | 242 | 19 |
| GOLIMUMAB | 228 | 0.3% | 1 | 219 | 5 |
| WARFARIN | 214 | 0.5% | 34 | 128 | 15 |
| AZATHIOPRINE | 184 | 0.6% | 27 | 159 | 23 |
| IBUPROFEN | 184 | 0.2% | 1 | 168 | 3 |
| USTEKINUMAB | 159 | 0.2% | 2 | 150 | 2 |