Does BINIMETINIB Cause Cholestasis? 21 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 21 reports of Cholestasis have been filed in association with BINIMETINIB (MEKTOVI). This represents 0.3% of all adverse event reports for BINIMETINIB.
21
Reports of Cholestasis with BINIMETINIB
0.3%
of all BINIMETINIB reports
1
Deaths
10
Hospitalizations
How Dangerous Is Cholestasis From BINIMETINIB?
Of the 21 reports, 1 (4.8%) resulted in death, 10 (47.6%) required hospitalization, and 4 (19.0%) were considered life-threatening.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for BINIMETINIB. However, 21 reports have been filed with the FAERS database.
What Other Side Effects Does BINIMETINIB Cause?
Off label use (902)
Death (719)
Nausea (657)
Fatigue (562)
Diarrhoea (521)
Product use in unapproved indication (508)
Pyrexia (490)
Neoplasm progression (387)
Vomiting (375)
Rash (360)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which BINIMETINIB Alternatives Have Lower Cholestasis Risk?
BINIMETINIB vs BIOFLAVONOIDS
BINIMETINIB vs BIOTIN
BINIMETINIB vs BIPERIDEN
BINIMETINIB vs BIRCH TRITERPENES
BINIMETINIB vs BISACODYL