Does CRIZOTINIB Cause Osteonecrosis? 24 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 24 reports of Osteonecrosis have been filed in association with CRIZOTINIB (Xalkori). This represents 0.2% of all adverse event reports for CRIZOTINIB.
24
Reports of Osteonecrosis with CRIZOTINIB
0.2%
of all CRIZOTINIB reports
13
Deaths
1
Hospitalizations
How Dangerous Is Osteonecrosis From CRIZOTINIB?
Of the 24 reports, 13 (54.2%) resulted in death, 1 (4.2%) required hospitalization.
Is Osteonecrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for CRIZOTINIB. However, 24 reports have been filed with the FAERS database.
What Other Side Effects Does CRIZOTINIB Cause?
Death (2,028)
Neoplasm progression (1,161)
Nausea (820)
Disease progression (677)
Diarrhoea (631)
Vomiting (600)
Fatigue (419)
Off label use (353)
Dyspnoea (352)
Visual impairment (315)
What Other Drugs Cause Osteonecrosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (8,935)
TENOFOVIR DISOPROXIL (7,182)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,338)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (2,081)
EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL (1,492)
PREDNISONE (779)
PREDNISOLONE (711)
DENOSUMAB (567)
METHOTREXATE (563)
DEXAMETHASONE (531)
Which CRIZOTINIB Alternatives Have Lower Osteonecrosis Risk?
CRIZOTINIB vs CROFELEMER
CRIZOTINIB vs CROMOLYN
CRIZOTINIB vs CROTALIDAE POLYVALENT IMMUNE FAB
CRIZOTINIB vs CUBICIN
CRIZOTINIB vs CUPRIC