Osteonecrosis: Which Medications Cause It? (19,409 Reports Across 457 Drugs)
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Osteonecrosis has been reported as an adverse event with 457 different drugs in the FDA's FAERS database, with 19,409 total reports. 364 of these reports resulted in death.The drugs most commonly associated with Osteonecrosis are EMTRICITABINE\TENOFOVIR DISOPROXIL, TENOFOVIR DISOPROXIL, and EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL.
19,409
Total Reports
457
Drugs Involved
364
Deaths
3,204
Hospitalizations
48.9 yrs
Average Patient Age
40.2% / 59.8%
Female / Male
Which Drugs Cause Osteonecrosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| EMTRICITABINE\TENOFOVIR DISOPROXIL | 8,935 | 22.7% | 116 | 514 | 0 |
| TENOFOVIR DISOPROXIL | 7,182 | 26.6% | 107 | 427 | 0 |
| EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL | 4,338 | 23.4% | 44 | 241 | 0 |
| COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL | 2,081 | 24.7% | 22 | 113 | 0 |
| EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL | 1,492 | 20.7% | 22 | 78 | 0 |
| PREDNISONE | 779 | 0.5% | 17 | 249 | 26 |
| PREDNISOLONE | 711 | 0.9% | 42 | 253 | 34 |
| DENOSUMAB | 567 | 0.4% | 15 | 94 | 2 |
| METHOTREXATE | 563 | 0.2% | 32 | 149 | 28 |
| DEXAMETHASONE | 531 | 0.4% | 26 | 137 | 16 |
| ZOLEDRONIC ACID | 511 | 1.5% | 12 | 156 | 8 |
| METHYLPREDNISOLONE | 485 | 0.8% | 21 | 177 | 9 |
| ADALIMUMAB | 338 | 0.1% | 8 | 128 | 5 |
| CYCLOPHOSPHAMIDE | 311 | 0.2% | 16 | 70 | 19 |
| ALENDRONATE | 305 | 1.1% | 4 | 112 | 1 |
| VINCRISTINE | 256 | 0.4% | 10 | 47 | 4 |
| MYCOPHENOLATE MOFETIL | 223 | 0.3% | 15 | 62 | 19 |
| DOXORUBICIN | 200 | 0.2% | 11 | 30 | 3 |
| CYCLOSPORINE | 197 | 0.3% | 19 | 87 | 4 |
| RITUXIMAB | 195 | 0.1% | 13 | 64 | 25 |
Top 3 Drugs Associated With Osteonecrosis
8,935 reports
7,182 reports
4,338 reports