Does METHOTREXATE Cause Osteonecrosis? 563 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 563 reports of Osteonecrosis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
563
Reports of Osteonecrosis with METHOTREXATE
0.2%
of all METHOTREXATE reports
32
Deaths
149
Hospitalizations
How Dangerous Is Osteonecrosis From METHOTREXATE?
Of the 563 reports, 32 (5.7%) resulted in death, 149 (26.5%) required hospitalization, and 28 (5.0%) were considered life-threatening.
Is Osteonecrosis Listed in the Official Label?
Yes, Osteonecrosis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Osteonecrosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (8,935)
TENOFOVIR DISOPROXIL (7,182)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,338)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (2,081)
EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL (1,492)
PREDNISONE (779)
PREDNISOLONE (711)
DENOSUMAB (567)
DEXAMETHASONE (531)
ZOLEDRONIC ACID (511)
Which METHOTREXATE Alternatives Have Lower Osteonecrosis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA