Does DARATUMUMAB Cause Hypercalcaemia? 135 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 135 reports of Hypercalcaemia have been filed in association with DARATUMUMAB (DARZALEX). This represents 0.5% of all adverse event reports for DARATUMUMAB.
135
Reports of Hypercalcaemia with DARATUMUMAB
0.5%
of all DARATUMUMAB reports
23
Deaths
51
Hospitalizations
How Dangerous Is Hypercalcaemia From DARATUMUMAB?
Of the 135 reports, 23 (17.0%) resulted in death, 51 (37.8%) required hospitalization, and 9 (6.7%) were considered life-threatening.
Is Hypercalcaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for DARATUMUMAB. However, 135 reports have been filed with the FAERS database.
What Other Side Effects Does DARATUMUMAB Cause?
Plasma cell myeloma (2,980)
Infusion related reaction (2,557)
Off label use (2,494)
Pneumonia (1,450)
Neutropenia (1,351)
Drug ineffective (1,110)
Thrombocytopenia (1,089)
Death (1,088)
Pyrexia (1,032)
Dyspnoea (996)
What Other Drugs Cause Hypercalcaemia?
RITUXIMAB (857)
METHOTREXATE (803)
ADALIMUMAB (663)
TOCILIZUMAB (618)
ABATACEPT (612)
ETANERCEPT (602)
DENOSUMAB (599)
ALENDRONATE (594)
INFLIXIMAB (594)
LEFLUNOMIDE (585)
Which DARATUMUMAB Alternatives Have Lower Hypercalcaemia Risk?
DARATUMUMAB vs DARATUMUMAB\HYALURONIDASE-FIHJ
DARATUMUMAB vs DARBEPOETIN ALFA
DARATUMUMAB vs DARIDOREXANT
DARATUMUMAB vs DARIFENACIN HYDROBROMIDE
DARATUMUMAB vs DAROLUTAMIDE