Does METHOTREXATE Cause Hypercalcaemia? 803 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 803 reports of Hypercalcaemia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.3% of all adverse event reports for METHOTREXATE.
803
Reports of Hypercalcaemia with METHOTREXATE
0.3%
of all METHOTREXATE reports
19
Deaths
739
Hospitalizations
How Dangerous Is Hypercalcaemia From METHOTREXATE?
Of the 803 reports, 19 (2.4%) resulted in death, 739 (92.0%) required hospitalization, and 53 (6.6%) were considered life-threatening.
Is Hypercalcaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 803 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hypercalcaemia?
RITUXIMAB (857)
ADALIMUMAB (663)
TOCILIZUMAB (618)
ABATACEPT (612)
ETANERCEPT (602)
DENOSUMAB (599)
ALENDRONATE (594)
INFLIXIMAB (594)
LEFLUNOMIDE (585)
CODEINE (567)
Which METHOTREXATE Alternatives Have Lower Hypercalcaemia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA