Does IVACAFTOR Cause Hepatic necrosis? 14 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 14 reports of Hepatic necrosis have been filed in association with IVACAFTOR (Kalydeco). This represents 0.2% of all adverse event reports for IVACAFTOR.
14
Reports of Hepatic necrosis with IVACAFTOR
0.2%
of all IVACAFTOR reports
0
Deaths
11
Hospitalizations
How Dangerous Is Hepatic necrosis From IVACAFTOR?
Of the 14 reports, 11 (78.6%) required hospitalization.
Is Hepatic necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IVACAFTOR. However, 14 reports have been filed with the FAERS database.
What Other Side Effects Does IVACAFTOR Cause?
Hospitalisation (1,209)
Infective pulmonary exacerbation of cystic fibrosis (550)
Infection (227)
Malaise (226)
Lower respiratory tract infection (224)
Pneumonia (215)
Death (203)
Cough (180)
Cystic fibrosis (167)
Headache (163)
What Other Drugs Cause Hepatic necrosis?
ACETAMINOPHEN (216)
CYCLOPHOSPHAMIDE (83)
PREDNISONE (78)
VENLAFAXINE (69)
TACROLIMUS (67)
MYCOPHENOLATE MOFETIL (61)
METHOTREXATE (55)
METHYLPREDNISOLONE (55)
SOMATROPIN (50)
DIMETHYL SULFONE (49)
Which IVACAFTOR Alternatives Have Lower Hepatic necrosis Risk?
IVACAFTOR vs IVACAFTOR\LUMACAFTOR
IVACAFTOR vs IVACAFTOR\TEZACAFTOR
IVACAFTOR vs IVERMECTIN
IVACAFTOR vs IVOSIDENIB
IVACAFTOR vs IXABEPILONE