Hepatic necrosis: Which Medications Cause It? (1,667 Reports Across 247 Drugs)
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Hepatic necrosis has been reported as an adverse event with 247 different drugs in the FDA's FAERS database, with 1,667 total reports. 650 of these reports resulted in death.The drugs most commonly associated with Hepatic necrosis are ACETAMINOPHEN, CYCLOPHOSPHAMIDE, and PREDNISONE.
1,667
Total Reports
247
Drugs Involved
650
Deaths
1,056
Hospitalizations
47.2 yrs
Average Patient Age
61.7% / 38.3%
Female / Male
Which Drugs Cause Hepatic necrosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 216 | 0.2% | 92 | 153 | 54 |
| CYCLOPHOSPHAMIDE | 83 | 0.1% | 61 | 40 | 15 |
| PREDNISONE | 78 | 0.1% | 61 | 61 | 34 |
| VENLAFAXINE | 69 | 0.1% | 12 | 59 | 1 |
| TACROLIMUS | 67 | 0.1% | 46 | 52 | 16 |
| MYCOPHENOLATE MOFETIL | 61 | 0.1% | 42 | 52 | 23 |
| METHOTREXATE | 55 | 0.0% | 23 | 20 | 8 |
| METHYLPREDNISOLONE | 55 | 0.1% | 35 | 42 | 26 |
| SOMATROPIN | 50 | 0.1% | 1 | 50 | 0 |
| DIMETHYL SULFONE | 49 | 48.0% | 0 | 49 | 0 |
| ESTRADIOL | 49 | 0.2% | 0 | 49 | 0 |
| LORAZEPAM | 48 | 0.1% | 1 | 48 | 0 |
| PROGESTERONE | 48 | 0.9% | 0 | 48 | 0 |
| VARENICLINE | 48 | 0.2% | 0 | 48 | 0 |
| ATORVASTATIN | 46 | 0.1% | 7 | 34 | 3 |
| BUDESONIDE\FORMOTEROL | 43 | 0.1% | 1 | 43 | 0 |
| BUSULFAN | 42 | 0.4% | 33 | 22 | 2 |
| LAMOTRIGINE | 40 | 0.1% | 23 | 34 | 21 |
| VINCRISTINE | 39 | 0.1% | 23 | 15 | 12 |
| DIAZEPAM | 37 | 0.1% | 21 | 15 | 2 |