Does LAPATINIB Cause Cholestasis? 22 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 22 reports of Cholestasis have been filed in association with LAPATINIB. This represents 1.1% of all adverse event reports for LAPATINIB.
22
Reports of Cholestasis with LAPATINIB
1.1%
of all LAPATINIB reports
4
Deaths
3
Hospitalizations
How Dangerous Is Cholestasis From LAPATINIB?
Of the 22 reports, 4 (18.2%) resulted in death, 3 (13.6%) required hospitalization.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LAPATINIB. However, 22 reports have been filed with the FAERS database.
What Other Side Effects Does LAPATINIB Cause?
Diarrhoea (382)
Disease progression (227)
Palmar-plantar erythrodysaesthesia syndrome (182)
Malignant neoplasm progression (173)
Nausea (161)
Metastases to central nervous system (160)
Neutropenia (160)
Vomiting (155)
Asthenia (148)
Fatigue (139)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which LAPATINIB Alternatives Have Lower Cholestasis Risk?
LAPATINIB vs LAPATINIB DITOSYLATE
LAPATINIB vs LAPINE T-LYMPHOCYTE IMMUNE GLOBULIN
LAPATINIB vs LARONIDASE
LAPATINIB vs LAROTRECTINIB
LAPATINIB vs LASILIX