Does LETROZOLE Cause Hepatic necrosis? 30 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 30 reports of Hepatic necrosis have been filed in association with LETROZOLE (Letrozole). This represents 0.1% of all adverse event reports for LETROZOLE.
30
Reports of Hepatic necrosis with LETROZOLE
0.1%
of all LETROZOLE reports
21
Deaths
27
Hospitalizations
How Dangerous Is Hepatic necrosis From LETROZOLE?
Of the 30 reports, 21 (70.0%) resulted in death, 27 (90.0%) required hospitalization, and 1 (3.3%) were considered life-threatening.
Is Hepatic necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LETROZOLE. However, 30 reports have been filed with the FAERS database.
What Other Side Effects Does LETROZOLE Cause?
Neutropenia (3,683)
Fatigue (3,568)
Malignant neoplasm progression (3,445)
Nausea (2,894)
Arthralgia (2,318)
Diarrhoea (2,282)
Metastases to bone (1,735)
Dyspnoea (1,621)
Asthenia (1,589)
Vomiting (1,560)
What Other Drugs Cause Hepatic necrosis?
ACETAMINOPHEN (216)
CYCLOPHOSPHAMIDE (83)
PREDNISONE (78)
VENLAFAXINE (69)
TACROLIMUS (67)
MYCOPHENOLATE MOFETIL (61)
METHOTREXATE (55)
METHYLPREDNISOLONE (55)
SOMATROPIN (50)
DIMETHYL SULFONE (49)
Which LETROZOLE Alternatives Have Lower Hepatic necrosis Risk?
LETROZOLE vs LETROZOLE\RIBOCICLIB
LETROZOLE vs LEUCOVORIN
LETROZOLE vs LEUCOVORIN\LEUCOVORIN
LETROZOLE vs LEUPROLIDE
LETROZOLE vs LEVALBUTEROL