Does MERCAPTOPURINE Cause Osteonecrosis? 115 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 115 reports of Osteonecrosis have been filed in association with MERCAPTOPURINE (Mercaptopurine). This represents 1.0% of all adverse event reports for MERCAPTOPURINE.
115
Reports of Osteonecrosis with MERCAPTOPURINE
1.0%
of all MERCAPTOPURINE reports
5
Deaths
41
Hospitalizations
How Dangerous Is Osteonecrosis From MERCAPTOPURINE?
Of the 115 reports, 5 (4.3%) resulted in death, 41 (35.7%) required hospitalization, and 3 (2.6%) were considered life-threatening.
Is Osteonecrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MERCAPTOPURINE. However, 115 reports have been filed with the FAERS database.
What Other Side Effects Does MERCAPTOPURINE Cause?
Febrile neutropenia (1,853)
Off label use (893)
Pyrexia (855)
Drug ineffective (721)
Vomiting (488)
Neutropenia (485)
Nausea (418)
Pneumonia (394)
Pancytopenia (392)
Sepsis (389)
What Other Drugs Cause Osteonecrosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (8,935)
TENOFOVIR DISOPROXIL (7,182)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,338)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (2,081)
EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL (1,492)
PREDNISONE (779)
PREDNISOLONE (711)
DENOSUMAB (567)
METHOTREXATE (563)
DEXAMETHASONE (531)
Which MERCAPTOPURINE Alternatives Have Lower Osteonecrosis Risk?
MERCAPTOPURINE vs MEROPENEM
MERCAPTOPURINE vs MEROPENEM ANHYDROUS
MERCAPTOPURINE vs MESALAMINE
MERCAPTOPURINE vs MESNA
MERCAPTOPURINE vs METAMIZOLE