Does METFORMIN Cause Hepatic necrosis? 18 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 18 reports of Hepatic necrosis have been filed in association with METFORMIN (Metformin Hydrochloride). This represents 0.0% of all adverse event reports for METFORMIN.
18
Reports of Hepatic necrosis with METFORMIN
0.0%
of all METFORMIN reports
12
Deaths
14
Hospitalizations
How Dangerous Is Hepatic necrosis From METFORMIN?
Of the 18 reports, 12 (66.7%) resulted in death, 14 (77.8%) required hospitalization, and 6 (33.3%) were considered life-threatening.
Is Hepatic necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METFORMIN. However, 18 reports have been filed with the FAERS database.
What Other Side Effects Does METFORMIN Cause?
Lactic acidosis (16,316)
Acute kidney injury (11,361)
Diarrhoea (7,679)
Toxicity to various agents (5,669)
Metabolic acidosis (5,236)
Hypoglycaemia (5,047)
Drug ineffective (4,991)
Nausea (4,915)
Vomiting (4,624)
Blood glucose increased (4,038)
What Other Drugs Cause Hepatic necrosis?
ACETAMINOPHEN (216)
CYCLOPHOSPHAMIDE (83)
PREDNISONE (78)
VENLAFAXINE (69)
TACROLIMUS (67)
MYCOPHENOLATE MOFETIL (61)
METHOTREXATE (55)
METHYLPREDNISOLONE (55)
SOMATROPIN (50)
DIMETHYL SULFONE (49)
Which METFORMIN Alternatives Have Lower Hepatic necrosis Risk?
METFORMIN vs METFORMIN\PIOGLITAZONE
METFORMIN vs METFORMIN\ROSIGLITAZONE
METFORMIN vs METFORMIN\SAXAGLIPTIN
METFORMIN vs METFORMIN\SITAGLIPTIN
METFORMIN vs METFORMIN\VILDAGLIPTIN