PEMETREXED for K-ras gene mutation: Side Effects & Safety Data
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There are 16 adverse event reports in the FDA FAERS database where PEMETREXED was used for K-ras gene mutation.
Most Reported Side Effects for PEMETREXED
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Malignant neoplasm progression | 2,149 | 9.1% | 613 | 587 |
| Off label use | 1,663 | 7.1% | 308 | 652 |
| Anaemia | 1,430 | 6.1% | 173 | 745 |
| Pancytopenia | 1,236 | 5.3% | 286 | 861 |
| Neutropenia | 1,200 | 5.1% | 212 | 505 |
| Nausea | 1,195 | 5.1% | 164 | 579 |
| Diarrhoea | 1,165 | 5.0% | 273 | 706 |
| Acute kidney injury | 1,105 | 4.7% | 169 | 773 |
| Thrombocytopenia | 1,059 | 4.5% | 195 | 540 |
| Disease progression | 969 | 4.1% | 184 | 134 |
| Vomiting | 903 | 3.8% | 149 | 548 |
| Fatigue | 867 | 3.7% | 91 | 305 |
| Febrile neutropenia | 852 | 3.6% | 250 | 574 |
| Drug ineffective | 838 | 3.6% | 179 | 206 |
| Death | 808 | 3.4% | 807 | 187 |
Other Indications for PEMETREXED
Non-small cell lung cancer (5,179)
Lung adenocarcinoma (4,280)
Lung neoplasm malignant (2,422)
Product used for unknown indication (1,640)
Lung adenocarcinoma stage iv (1,510)
Non-small cell lung cancer metastatic (1,426)
Non-small cell lung cancer stage iv (782)
Bronchial carcinoma (712)
Pleural mesothelioma malignant (427)
Adenocarcinoma (374)
Other Drugs Used for K-ras gene mutation
SOTORASIB (752)
AMG-510 (173)
IRINOTECAN (40)
PANITUMUMAB (36)
CETUXIMAB (29)
PEMBROLIZUMAB (28)
BEVACIZUMAB (19)
DALOTUZUMAB (18)
CARBOPLATIN (17)
FLUOROURACIL (17)