Does PEMETREXED Cause Cholestasis? 107 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 107 reports of Cholestasis have been filed in association with PEMETREXED (Pemetrexed). This represents 0.5% of all adverse event reports for PEMETREXED.
107
Reports of Cholestasis with PEMETREXED
0.5%
of all PEMETREXED reports
3
Deaths
65
Hospitalizations
How Dangerous Is Cholestasis From PEMETREXED?
Of the 107 reports, 3 (2.8%) resulted in death, 65 (60.7%) required hospitalization, and 2 (1.9%) were considered life-threatening.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMETREXED. However, 107 reports have been filed with the FAERS database.
What Other Side Effects Does PEMETREXED Cause?
Malignant neoplasm progression (2,149)
Off label use (1,663)
Anaemia (1,430)
Pancytopenia (1,236)
Neutropenia (1,200)
Nausea (1,195)
Diarrhoea (1,165)
Acute kidney injury (1,105)
Thrombocytopenia (1,059)
Disease progression (969)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which PEMETREXED Alternatives Have Lower Cholestasis Risk?
PEMETREXED vs PEMIGATINIB
PEMETREXED vs PENICILLAMINE
PEMETREXED vs PENICILLIN
PEMETREXED vs PENICILLIN G
PEMETREXED vs PENICILLIN G BENZATHINE