Does PONATINIB Cause Osteonecrosis? 11 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 11 reports of Osteonecrosis have been filed in association with PONATINIB (Iclusig). This represents 0.1% of all adverse event reports for PONATINIB.
11
Reports of Osteonecrosis with PONATINIB
0.1%
of all PONATINIB reports
1
Deaths
6
Hospitalizations
How Dangerous Is Osteonecrosis From PONATINIB?
Of the 11 reports, 1 (9.1%) resulted in death, 6 (54.5%) required hospitalization.
Is Osteonecrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PONATINIB. However, 11 reports have been filed with the FAERS database.
What Other Side Effects Does PONATINIB Cause?
Death (1,735)
Off label use (1,071)
Product dose omission issue (817)
Fatigue (687)
Rash (639)
Headache (553)
Pyrexia (542)
Nausea (466)
Hospitalisation (459)
Constipation (435)
What Other Drugs Cause Osteonecrosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (8,935)
TENOFOVIR DISOPROXIL (7,182)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,338)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (2,081)
EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL (1,492)
PREDNISONE (779)
PREDNISOLONE (711)
DENOSUMAB (567)
METHOTREXATE (563)
DEXAMETHASONE (531)
Which PONATINIB Alternatives Have Lower Osteonecrosis Risk?
PONATINIB vs PONATINIB\PONATINIB
PONATINIB vs PONESIMOD
PONATINIB vs PORACTANT ALFA
PONATINIB vs PORFIMER
PONATINIB vs POSACONAZOLE