SILTUXIMAB for Off label use: Side Effects & Safety Data
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There are 30 adverse event reports in the FDA FAERS database where SILTUXIMAB was used for Off label use.
Most Reported Side Effects for SILTUXIMAB
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Off label use | 96 | 20.3% | 27 | 27 |
| Drug ineffective | 72 | 15.3% | 16 | 42 |
| Disease progression | 32 | 6.8% | 17 | 5 |
| Immune effector cell-associated neurotoxicity syndrome | 28 | 5.9% | 16 | 4 |
| Death | 27 | 5.7% | 27 | 1 |
| Cytokine release syndrome | 26 | 5.5% | 18 | 9 |
| Hypertension | 24 | 5.1% | 2 | 18 |
| Product use in unapproved indication | 24 | 5.1% | 9 | 5 |
| Drug effective for unapproved indication | 23 | 4.9% | 0 | 0 |
| Cataract | 19 | 4.0% | 0 | 17 |
| Condition aggravated | 19 | 4.0% | 16 | 4 |
| Cushingoid | 17 | 3.6% | 0 | 15 |
| Fracture | 17 | 3.6% | 0 | 15 |
| Hepatic steatosis | 17 | 3.6% | 0 | 15 |
| Osteopenia | 17 | 3.6% | 0 | 15 |
Other Indications for SILTUXIMAB
Castleman's disease (222)
Cytokine release syndrome (72)
Product used for unknown indication (72)
Still's disease (20)
Plasma cell myeloma (16)
Haemophagocytic lymphohistiocytosis (13)
Immune effector cell-associated neurotoxicity syndrome (12)
Poems syndrome (8)
Drug reaction with eosinophilia and systemic symptoms (7)
Pancreatic carcinoma metastatic (7)
Other Drugs Used for Off label use
LENALIDOMIDE (5,767)
ECULIZUMAB (3,550)
CERTOLIZUMAB PEGOL (2,256)
ABOBOTULINUMTOXINA (2,170)
LEVETIRACETAM (2,161)
APREMILAST (1,995)
PROPRANOLOL (1,576)
CETIRIZINE (1,416)
HUMAN IMMUNOGLOBULIN G (1,129)
THALIDOMIDE (1,033)