Does TOPIRAMATE Cause Hepatic failure? 26 Reports in FDA Database

Q: Does TOPIRAMATE cause Hepatic failure?

26 reports of Hepatic failure have been filed with the FDA for TOPIRAMATE, representing 0.1% of all TOPIRAMATE adverse event reports.

Q: How dangerous is Hepatic failure from TOPIRAMATE?

Of 26 reports, 14 (53.8%) resulted in death and 9 required hospitalization.

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According to the FDA Adverse Event Reporting System (FAERS), 26 reports of Hepatic failure have been filed in association with TOPIRAMATE (Topiramate). This represents 0.1% of all adverse event reports for TOPIRAMATE.

Reports of Hepatic failure with TOPIRAMATE

0.1%

of all TOPIRAMATE reports

Deaths

Hospitalizations

How Dangerous Is Hepatic failure From TOPIRAMATE?

Of the 26 reports, 14 (53.8%) resulted in death, 9 (34.6%) required hospitalization, and 7 (26.9%) were considered life-threatening.

Is Hepatic failure Listed in the Official Label?

Yes, Hepatic failure is listed as a known adverse reaction in the official FDA drug label for TOPIRAMATE.

What Other Side Effects Does TOPIRAMATE Cause?

Drug ineffective (5,553) Off label use (4,248) Product use in unapproved indication (2,173) Headache (1,997) Drug intolerance (1,820) Migraine (1,796) Nausea (1,691) Seizure (1,535) Paraesthesia (1,506) Dizziness (1,466)

What Other Drugs Cause Hepatic failure?

ACETAMINOPHEN (1,392) RIBAVIRIN (888) CYCLOPHOSPHAMIDE (629) METHOTREXATE (598) BEVACIZUMAB (558) SOFOSBUVIR (525) RITUXIMAB (513) VINCRISTINE (468) DOXORUBICIN (462) PREDNISOLONE (425)

Which TOPIRAMATE Alternatives Have Lower Hepatic failure Risk?

TOPIRAMATE vs TOPOTECAN TOPIRAMATE vs TOPOTECAN\TOPOTECAN TOPIRAMATE vs TOPROL TOPIRAMATE vs TOREMIFENE TOPIRAMATE vs TORIPALIMAB

TOPIRAMATE Full Profile All Hepatic failure Reports All Drugs Causing Hepatic failure TOPIRAMATE Demographics