Hepatic failure: Which Medications Cause It? (18,777 Reports Across 850 Drugs)
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Hepatic failure has been reported as an adverse event with 850 different drugs in the FDA's FAERS database, with 18,777 total reports. 9,179 of these reports resulted in death.The drugs most commonly associated with Hepatic failure are ACETAMINOPHEN, RIBAVIRIN, and CYCLOPHOSPHAMIDE.
18,777
Total Reports
850
Drugs Involved
9,179
Deaths
9,723
Hospitalizations
54.3 yrs
Average Patient Age
51.0% / 49.0%
Female / Male
Which Drugs Cause Hepatic failure Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 1,392 | 1.0% | 554 | 825 | 301 |
| RIBAVIRIN | 888 | 2.1% | 302 | 511 | 60 |
| CYCLOPHOSPHAMIDE | 629 | 0.5% | 437 | 227 | 81 |
| METHOTREXATE | 598 | 0.2% | 303 | 327 | 130 |
| BEVACIZUMAB | 558 | 0.7% | 344 | 181 | 48 |
| SOFOSBUVIR | 525 | 3.0% | 178 | 329 | 22 |
| RITUXIMAB | 513 | 0.3% | 380 | 147 | 74 |
| VINCRISTINE | 468 | 0.7% | 344 | 168 | 57 |
| DOXORUBICIN | 462 | 0.6% | 334 | 143 | 62 |
| PREDNISOLONE | 425 | 0.5% | 330 | 184 | 81 |
| NIVOLUMAB | 382 | 0.4% | 252 | 229 | 65 |
| TACROLIMUS | 372 | 0.4% | 268 | 218 | 96 |
| ATEZOLIZUMAB | 371 | 1.1% | 221 | 136 | 21 |
| PREDNISONE | 360 | 0.2% | 237 | 204 | 74 |
| PACLITAXEL | 348 | 0.5% | 198 | 168 | 63 |
| RIFAXIMIN | 321 | 2.3% | 243 | 146 | 5 |
| ATORVASTATIN | 286 | 0.4% | 106 | 180 | 74 |
| IBUPROFEN | 281 | 0.3% | 91 | 207 | 75 |
| METFORMIN | 281 | 0.3% | 142 | 184 | 67 |
| PEMBROLIZUMAB | 277 | 0.3% | 148 | 167 | 50 |