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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Constipation: Which Medications Are Safest? (552 Drugs Compared)

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552 medications are used for Constipation, with 25,612 combined adverse event reports. The most reported drugs for Constipation are POLYETHYLENE GLYCOL 3350 and LINACLOTIDE.

25,612
Total Reports
552
Drugs Used

All Medications for Constipation Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
POLYETHYLENE GLYCOL 3350 Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride - Unflavored 9,960 478 1,116 1.3%
LINACLOTIDE Linzess 5,348 358 756 2.7%
NALOXEGOL OXALATE MOVANTIK 1,418 154 335 7.0%
LACTULOSE LACTULOSE 1,115 517 2,064 13.0%
BISACODYL Gentle Laxative 1,013 414 1,415 11.9%
POLYETHYLENE GLYCOL 3350\POTASSIUM\SODIUM BICARBONATE\SODIUM - 709 251 1,010 10.4%
POLYETHYLENE GLYCOLS - 667 384 837 21.4%
MAGNESIUM citroma 648 1,878 4,530 19.3%
MAGNESIUM HYDROXIDE MILK OF MAGNESIA 635 152 899 7.7%
LUBIPROSTONE Amitza 563 118 332 9.7%
PLECANATIDE Trulance Immediate release 504 45 50 4.7%
PRUCALOPRIDE Prucalopride 498 33 199 2.3%
POLYETHYLENE GLYCOL 4000 - 490 246 521 25.0%
DOCUSATE SENNA-S 470 374 1,178 14.3%
MIRALAX - 419 9 26 0.7%
BISACODYL OR DOCUSATE - 411 89 397 9.1%
METHYLNALTREXONE Relistor 388 242 108 29.3%
SODIUM PICOSULFATE - 357 614 375 55.2%
NALDEMEDINE SYMPROIC 340 167 105 24.7%
SENNOSIDES Geri-kot 224 323 833 14.1%

View all 552 drugs →

Most Reported Drugs for Constipation

#1 most reported
#2 most reported
#3 most reported