Alkylating Activity [MoA]: Side Effects & Safety Data for 16 Drugs
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Alkylating Activity [MoA] includes 16 drugs with a combined 114,376 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
16
Drugs in Class
114,376
Combined Reports
All Alkylating Activity [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| BENDAMUSTINE | VIVIMUSTA | 19,667 | 3,988 | 7,576 | 20.3% |
| TEMOZOLOMIDE | TEMOZOLOMIDE | 17,007 | 3,099 | 4,302 | 18.2% |
| IFOSFAMIDE | IFEX | 17,004 | 3,365 | 5,230 | 19.8% |
| MELPHALAN | Melphalan Hydrochloride | 16,061 | 3,369 | 4,615 | 21.0% |
| BUSULFAN | Busulfan | 11,254 | 3,122 | 2,271 | 27.7% |
| THIOTEPA | Thiotepa | 6,836 | 1,867 | 1,184 | 27.3% |
| PROCARBAZINE | Matulane | 6,373 | 829 | 1,132 | 13.0% |
| DACARBAZINE | Dacarbazine | 5,105 | 847 | 1,914 | 16.6% |
| CARMUSTINE | carmustine | 3,376 | 781 | 873 | 23.1% |
| MECHLORETHAMINE | VALCHLOR | 2,579 | 266 | 291 | 10.3% |
| CHLORAMBUCIL | LEUKERAN | 2,290 | 537 | 929 | 23.4% |
| MITOMYCIN | MUTAMYCIN | 2,111 | 231 | 590 | 10.9% |
| TRABECTEDIN | YONDELIS | 1,957 | 376 | 896 | 19.2% |
| LOMUSTINE | LOMUSTINE | 1,614 | 431 | 418 | 26.7% |
| LURBINECTEDIN | ZEPZELCA | 966 | 252 | 337 | 26.1% |
| STREPTOZOCIN | Zanosar | 176 | 40 | 56 | 22.7% |
Common Side Effects in Alkylating Activity [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Off label use | 12,615 | 2,682 |
| Disease progression | 8,062 | 2,045 |
| Febrile neutropenia | 7,375 | 1,016 |
| Drug ineffective | 6,491 | 1,635 |
| Neutropenia | 6,456 | 1,166 |
| Product use in unapproved indication | 6,276 | 1,152 |
| Thrombocytopenia | 5,943 | 990 |
| Pyrexia | 4,838 | 825 |
| Nausea | 4,466 | 344 |
| Death | 4,041 | 3,992 |