Alkylating Activity [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Off label use | 12,615 | 16 | 2,682 | 3,180 | 1,070 |
| Disease progression | 8,062 | 16 | 2,045 | 1,031 | 248 |
| Febrile neutropenia | 7,375 | 14 | 1,016 | 3,508 | 884 |
| Drug ineffective | 6,491 | 16 | 1,635 | 1,532 | 579 |
| Neutropenia | 6,456 | 16 | 1,166 | 1,976 | 856 |
| Product use in unapproved indication | 6,276 | 16 | 1,152 | 1,135 | 371 |
| Thrombocytopenia | 5,943 | 16 | 990 | 1,876 | 807 |
| Pyrexia | 4,838 | 15 | 825 | 2,900 | 551 |
| Nausea | 4,466 | 16 | 344 | 1,384 | 319 |
| Death | 4,041 | 15 | 3,992 | 440 | 102 |
| Anaemia | 3,982 | 16 | 590 | 1,341 | 458 |
| Diarrhoea | 3,481 | 16 | 579 | 1,624 | 296 |
| Mucosal inflammation | 3,412 | 12 | 556 | 1,118 | 563 |
| Pneumonia | 3,365 | 15 | 1,277 | 1,886 | 468 |
| Sepsis | 3,320 | 16 | 1,783 | 1,445 | 518 |
| Infection | 3,220 | 15 | 1,339 | 643 | 168 |
| Fatigue | 3,156 | 16 | 318 | 803 | 197 |
| Vomiting | 3,090 | 16 | 418 | 1,342 | 318 |
| Malignant neoplasm progression | 3,020 | 16 | 963 | 688 | 131 |
| Pancytopenia | 2,960 | 15 | 721 | 1,292 | 388 |
| Acute kidney injury | 2,258 | 15 | 619 | 1,237 | 310 |
| Myelodysplastic syndrome | 2,100 | 15 | 900 | 417 | 190 |
| Cytomegalovirus infection | 2,067 | 10 | 576 | 619 | 187 |
| Acute myeloid leukaemia | 1,956 | 14 | 1,105 | 500 | 239 |
| Platelet count decreased | 1,775 | 14 | 216 | 655 | 168 |
| Venoocclusive liver disease | 1,754 | 9 | 584 | 470 | 206 |
| Rash | 1,712 | 14 | 234 | 471 | 89 |
| Cytopenia | 1,710 | 13 | 133 | 437 | 52 |
| Myelosuppression | 1,651 | 13 | 171 | 680 | 190 |
| Product use issue | 1,633 | 14 | 288 | 305 | 110 |