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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Product use issue: Which Medications Cause It? (173,127 Reports Across 1,797 Drugs)

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Product use issue has been reported as an adverse event with 1,797 different drugs in the FDA's FAERS database, with 173,127 total reports. 8,638 of these reports resulted in death.The drugs most commonly associated with Product use issue are INFLIXIMAB, DUPILUMAB, and POLYETHYLENE GLYCOL 3350.

173,127
Total Reports
1,797
Drugs Involved
8,638
Deaths
27,417
Hospitalizations
50.6 yrs
Average Patient Age
63.6% / 36.4%
Female / Male

Which Drugs Cause Product use issue Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
INFLIXIMAB 12,752 9.1% 1,066 3,577 1,392
DUPILUMAB 10,575 2.8% 42 691 11
POLYETHYLENE GLYCOL 3350 9,432 25.5% 43 87 4
METHOTREXATE 8,185 3.2% 1,094 2,427 1,432
DICLOFENAC 8,009 9.2% 1,026 1,377 1,202
RITUXIMAB 6,948 3.9% 1,389 2,224 1,344
ADALIMUMAB 6,379 1.3% 957 1,917 1,262
ETANERCEPT 6,062 1.7% 857 1,834 1,079
TOCILIZUMAB 5,944 6.0% 1,064 1,861 1,260
ABATACEPT 5,915 5.1% 874 1,759 1,203
CETIRIZINE 5,771 12.1% 976 1,295 1,182
GOLIMUMAB 5,669 8.2% 839 1,742 1,142
PREDNISONE 5,505 3.5% 1,024 1,772 1,299
HYDROXYCHLOROQUINE 5,413 8.1% 890 1,821 1,204
LEFLUNOMIDE 5,363 9.5% 969 1,836 1,301
MINOXIDIL 5,249 8.6% 1 19 2
CERTOLIZUMAB PEGOL 5,153 5.2% 804 1,548 1,136
USTEKINUMAB 5,008 5.9% 729 1,670 1,033
NAPROXEN 4,865 9.2% 624 987 831
ACETAMINOPHEN 4,854 3.6% 1,140 1,518 1,150

View all 1,797 drugs →

Top 3 Drugs Associated With Product use issue

12,752 reports
10,575 reports
9,432 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)