Venoocclusive liver disease: Which Medications Cause It? (3,617 Reports Across 166 Drugs)
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Venoocclusive liver disease has been reported as an adverse event with 166 different drugs in the FDA's FAERS database, with 3,617 total reports. 1,111 of these reports resulted in death.The drugs most commonly associated with Venoocclusive liver disease are CYCLOPHOSPHAMIDE, BUSULFAN, and FLUDARABINE.
3,617
Total Reports
166
Drugs Involved
1,111
Deaths
1,094
Hospitalizations
34.2 yrs
Average Patient Age
39.7% / 60.3%
Female / Male
Which Drugs Cause Venoocclusive liver disease Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CYCLOPHOSPHAMIDE | 911 | 0.7% | 295 | 269 | 130 |
| BUSULFAN | 765 | 6.8% | 250 | 190 | 71 |
| FLUDARABINE | 649 | 2.7% | 254 | 166 | 67 |
| VINCRISTINE | 616 | 0.9% | 113 | 184 | 81 |
| METHOTREXATE | 590 | 0.2% | 106 | 178 | 54 |
| CYTARABINE | 573 | 1.3% | 138 | 206 | 84 |
| ETOPOSIDE | 523 | 1.0% | 127 | 143 | 81 |
| OXALIPLATIN | 521 | 0.9% | 59 | 199 | 68 |
| MELPHALAN | 464 | 2.9% | 152 | 130 | 74 |
| DEXAMETHASONE | 371 | 0.3% | 64 | 111 | 36 |
| DEFIBROTIDE | 355 | 9.5% | 272 | 73 | 61 |
| TACROLIMUS | 319 | 0.4% | 133 | 127 | 51 |
| THIOTEPA | 306 | 4.5% | 115 | 59 | 27 |
| MYCOPHENOLATE MOFETIL | 286 | 0.4% | 120 | 88 | 35 |
| DOXORUBICIN | 262 | 0.3% | 63 | 97 | 44 |
| CYCLOSPORINE | 238 | 0.4% | 83 | 48 | 29 |
| INOTUZUMAB OZOGAMICIN | 229 | 9.9% | 114 | 72 | 35 |
| RITUXIMAB | 219 | 0.1% | 52 | 78 | 27 |
| CARBOPLATIN | 206 | 0.2% | 60 | 47 | 25 |
| FLUOROURACIL | 197 | 0.4% | 14 | 60 | 8 |