Does METHOTREXATE Cause Venoocclusive liver disease? 590 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 590 reports of Venoocclusive liver disease have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
590
Reports of Venoocclusive liver disease with METHOTREXATE
0.2%
of all METHOTREXATE reports
106
Deaths
178
Hospitalizations
How Dangerous Is Venoocclusive liver disease From METHOTREXATE?
Of the 590 reports, 106 (18.0%) resulted in death, 178 (30.2%) required hospitalization, and 54 (9.2%) were considered life-threatening.
Is Venoocclusive liver disease Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 590 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Venoocclusive liver disease?
CYCLOPHOSPHAMIDE (911)
BUSULFAN (765)
FLUDARABINE (649)
VINCRISTINE (616)
CYTARABINE (573)
ETOPOSIDE (523)
OXALIPLATIN (521)
MELPHALAN (464)
DEXAMETHASONE (371)
DEFIBROTIDE (355)
Which METHOTREXATE Alternatives Have Lower Venoocclusive liver disease Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA