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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Cytochrome P450 3A Inhibitors [MoA]: Side Effects & Safety Data for 31 Drugs

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Cytochrome P450 3A Inhibitors [MoA] includes 31 drugs with a combined 377,767 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.

31
Drugs in Class
377,767
Combined Reports

All Cytochrome P450 3A Inhibitors [MoA] Drugs Ranked by Reports

Drug Brand Name Reports Deaths Hosp. Death Rate
PALBOCICLIB Ibrance 91,024 11,066 13,442 12.2%
AMLODIPINE Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 64,924 10,161 26,787 15.7%
RIBOCICLIB KISQALI 27,997 4,501 6,700 16.1%
OSIMERTINIB TAGRISSO 27,750 12,456 5,277 44.9%
AMIODARONE Amiodarone Hydrochloride 25,143 3,845 13,711 15.3%
MIRABEGRON MIRABEGRON 20,618 1,338 2,589 6.5%
CLARITHROMYCIN Clarithromycin 18,945 987 6,385 5.2%
RITONAVIR Norvir 11,980 1,190 2,925 9.9%
CRIZOTINIB Xalkori 9,948 3,173 2,520 31.9%
RANOLAZINE Ranolazine 9,522 1,048 3,367 11.0%
SUVOREXANT BELSOMRA 9,413 219 572 2.3%
VERAPAMIL Verapamil Hydrochloride 9,320 2,630 3,576 28.2%
IDELALISIB Zydelig 6,862 1,548 2,962 22.6%
IVACAFTOR Kalydeco 6,735 291 3,756 4.3%
TUCATINIB TUKYSA 6,042 640 1,717 10.6%
CENOBAMATE Xcopri 5,643 125 1,012 2.2%
ATAZANAVIR Atazanavir Sulfate 5,434 425 1,112 7.8%
DARUNAVIR ETHANOLATE PREZISTA 4,389 397 1,069 9.0%
DARUNAVIR Darunavir 3,558 433 841 12.2%
CERITINIB ZYKADIA 2,796 786 804 28.1%
DRONEDARONE Multaq 2,735 115 611 4.2%
RITLECITINIB Litfulo 1,441 1 47 0.1%
LETERMOVIR PREVYMIS 1,416 252 398 17.8%
NELFINAVIR VIRACEPT 1,164 87 162 7.5%
SELPERCATINIB RETEVMO 1,084 160 342 14.8%
LENACAPAVIR Sunlenca 502 32 42 6.4%
NIROGACESTAT OGSIVEO 497 7 54 1.4%
PIRTOBRUTINIB JAYPIRCA 437 130 144 29.7%
COBICISTAT Tybost 347 41 109 11.8%
LONAFARNIB Zokinvy 59 6 14 10.2%
TRICLABENDAZOLE EGATEN 42 0 4 N/A

Common Side Effects in Cytochrome P450 3A Inhibitors [MoA] Drugs

Side EffectReportsDeaths
Fatigue 29,303 2,142
Death 29,071 29,002
Nausea 22,548 2,191
Drug ineffective 20,967 1,802
Diarrhoea 18,437 1,737
Dyspnoea 15,619 2,325
Off label use 14,972 2,567
White blood cell count decreased 13,750 592
Dizziness 13,175 1,163
Vomiting 13,058 1,982
View detailed side effects for this class → Compare drugs in this class →