Cytochrome P450 3A Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Fatigue | 29,303 | 28 | 2,142 | 6,311 | 1,391 |
| Death | 29,071 | 27 | 29,002 | 2,324 | 386 |
| Nausea | 22,548 | 29 | 2,191 | 7,062 | 1,432 |
| Drug ineffective | 20,967 | 29 | 1,802 | 5,148 | 1,879 |
| Diarrhoea | 18,437 | 30 | 1,737 | 5,552 | 1,007 |
| Dyspnoea | 15,619 | 26 | 2,325 | 7,347 | 1,524 |
| Off label use | 14,972 | 29 | 2,567 | 4,800 | 1,634 |
| White blood cell count decreased | 13,750 | 19 | 592 | 2,251 | 204 |
| Dizziness | 13,175 | 25 | 1,163 | 4,241 | 927 |
| Vomiting | 13,058 | 28 | 1,982 | 5,691 | 1,463 |
| Neoplasm progression | 12,745 | 13 | 1,957 | 1,787 | 100 |
| Headache | 12,262 | 26 | 941 | 3,363 | 802 |
| Asthenia | 12,108 | 26 | 1,948 | 4,965 | 1,288 |
| Malaise | 11,634 | 25 | 1,201 | 4,466 | 855 |
| Neutropenia | 11,250 | 22 | 632 | 1,966 | 471 |
| Pain | 10,570 | 26 | 1,198 | 4,071 | 1,037 |
| Hypotension | 10,099 | 22 | 1,279 | 7,351 | 2,262 |
| Alopecia | 9,330 | 22 | 669 | 1,571 | 536 |
| Rash | 9,109 | 28 | 932 | 2,452 | 828 |
| Toxicity to various agents | 8,950 | 22 | 3,710 | 5,666 | 2,000 |
| Drug interaction | 8,929 | 27 | 820 | 4,043 | 899 |
| Cough | 8,925 | 24 | 896 | 2,939 | 578 |
| Malignant neoplasm progression | 8,675 | 15 | 1,878 | 1,638 | 285 |
| Decreased appetite | 8,585 | 24 | 1,259 | 2,999 | 522 |
| Arthralgia | 8,174 | 25 | 945 | 2,185 | 650 |
| Fall | 8,165 | 22 | 995 | 5,227 | 835 |
| Constipation | 8,096 | 23 | 710 | 2,679 | 359 |
| Pneumonia | 7,474 | 26 | 1,865 | 4,794 | 1,096 |
| Pruritus | 6,955 | 25 | 545 | 1,552 | 319 |
| Pyrexia | 6,934 | 28 | 1,035 | 4,195 | 721 |