Nucleic Acid Synthesis Inhibitors [MoA]: Side Effects & Safety Data for 14 Drugs
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Nucleic Acid Synthesis Inhibitors [MoA] includes 14 drugs with a combined 288,606 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
14
Drugs in Class
288,606
Combined Reports
All Nucleic Acid Synthesis Inhibitors [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| CAPECITABINE | Capecitabine | 63,506 | 8,892 | 17,529 | 14.0% |
| FLUOROURACIL | FLUOROURACIL | 53,045 | 6,997 | 20,941 | 13.2% |
| CYTARABINE | cytarabine | 44,383 | 9,089 | 17,861 | 20.5% |
| AZATHIOPRINE | AZATHIOPRINE | 33,248 | 4,579 | 10,817 | 13.8% |
| GEMCITABINE | Gemcitabine | 31,328 | 5,142 | 12,268 | 16.4% |
| FLUDARABINE | Fludarabine Phosphate | 23,660 | 6,831 | 6,745 | 28.9% |
| AZACITIDINE | Azacitidine | 19,323 | 6,641 | 9,028 | 34.4% |
| MERCAPTOPURINE | Mercaptopurine | 11,490 | 1,468 | 5,925 | 12.8% |
| DECITABINE | Decitabine | 2,983 | 816 | 1,060 | 27.4% |
| DACTINOMYCIN | DACTINOMYCIN | 2,858 | 507 | 721 | 17.7% |
| CLOFARABINE | Clofarabine | 1,419 | 528 | 409 | 37.2% |
| NELARABINE | Nelarabine | 735 | 156 | 265 | 21.2% |
| PENTOSTATIN | Nipent | 455 | 109 | 121 | 24.0% |
| TRIFLURIDINE | Trifluridine | 173 | 26 | 34 | 15.0% |
Common Side Effects in Nucleic Acid Synthesis Inhibitors [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Off label use | 24,731 | 4,873 |
| Diarrhoea | 20,544 | 3,051 |
| Drug ineffective | 20,214 | 3,767 |
| Febrile neutropenia | 17,262 | 2,880 |
| Nausea | 16,616 | 2,192 |
| Neutropenia | 14,894 | 2,593 |
| Disease progression | 13,709 | 3,380 |
| Pyrexia | 13,423 | 2,236 |
| Vomiting | 12,199 | 2,070 |
| Fatigue | 12,119 | 1,933 |