Nucleic Acid Synthesis Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Off label use | 24,731 | 14 | 4,873 | 7,839 | 2,687 |
| Diarrhoea | 20,544 | 14 | 3,051 | 9,096 | 1,717 |
| Drug ineffective | 20,214 | 14 | 3,767 | 5,157 | 1,759 |
| Febrile neutropenia | 17,262 | 14 | 2,880 | 10,959 | 2,788 |
| Nausea | 16,616 | 14 | 2,192 | 6,878 | 1,262 |
| Neutropenia | 14,894 | 14 | 2,593 | 4,991 | 1,714 |
| Disease progression | 13,709 | 14 | 3,380 | 2,115 | 442 |
| Pyrexia | 13,423 | 13 | 2,236 | 9,148 | 1,541 |
| Vomiting | 12,199 | 14 | 2,070 | 6,505 | 1,203 |
| Fatigue | 12,119 | 14 | 1,933 | 4,427 | 986 |
| Thrombocytopenia | 11,648 | 14 | 2,089 | 4,408 | 1,596 |
| Death | 11,370 | 14 | 11,281 | 1,180 | 329 |
| Anaemia | 9,544 | 14 | 1,488 | 4,198 | 1,062 |
| Pneumonia | 9,125 | 13 | 3,843 | 5,048 | 1,693 |
| Product use in unapproved indication | 8,282 | 13 | 1,883 | 2,333 | 942 |
| Sepsis | 7,660 | 13 | 3,678 | 4,292 | 1,479 |
| Asthenia | 7,497 | 13 | 1,539 | 3,795 | 863 |
| Malignant neoplasm progression | 7,421 | 12 | 2,041 | 1,510 | 292 |
| Myelosuppression | 6,948 | 12 | 410 | 3,204 | 908 |
| Neuropathy peripheral | 6,730 | 13 | 523 | 1,224 | 211 |
| Palmar-plantar erythrodysaesthesia syndrome | 6,521 | 9 | 425 | 1,149 | 208 |
| Decreased appetite | 6,489 | 12 | 1,313 | 2,968 | 755 |
| Rash | 6,431 | 12 | 1,186 | 2,145 | 828 |
| Dyspnoea | 6,395 | 13 | 1,654 | 3,728 | 1,069 |
| Pancytopenia | 6,271 | 13 | 1,470 | 3,355 | 869 |
| Abdominal pain | 6,059 | 11 | 952 | 3,582 | 577 |
| Mucosal inflammation | 5,929 | 11 | 1,041 | 2,480 | 747 |
| Infection | 5,512 | 13 | 2,347 | 2,049 | 552 |
| Condition aggravated | 5,393 | 13 | 1,559 | 2,805 | 1,213 |
| Drug intolerance | 5,223 | 11 | 796 | 1,442 | 640 |