Palmar-plantar erythrodysaesthesia syndrome: Which Medications Cause It? (17,347 Reports Across 298 Drugs)
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Palmar-plantar erythrodysaesthesia syndrome has been reported as an adverse event with 298 different drugs in the FDA's FAERS database, with 17,347 total reports. 1,430 of these reports resulted in death.The drugs most commonly associated with Palmar-plantar erythrodysaesthesia syndrome are CAPECITABINE, CABOZANTINIB S-MALATE, and REGORAFENIB.
17,347
Total Reports
298
Drugs Involved
1,430
Deaths
3,737
Hospitalizations
61.0 yrs
Average Patient Age
53.8% / 46.2%
Female / Male
Which Drugs Cause Palmar-plantar erythrodysaesthesia syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CAPECITABINE | 5,294 | 8.3% | 312 | 808 | 157 |
| CABOZANTINIB S-MALATE | 2,706 | 6.9% | 119 | 349 | 13 |
| REGORAFENIB | 1,230 | 13.0% | 201 | 297 | 26 |
| LENVATINIB | 1,211 | 3.6% | 134 | 591 | 26 |
| BEVACIZUMAB | 1,079 | 1.4% | 137 | 216 | 31 |
| SORAFENIB | 1,040 | 9.5% | 202 | 233 | 24 |
| OXALIPLATIN | 980 | 1.7% | 82 | 242 | 56 |
| SUNITINIB MALATE | 929 | 4.3% | 103 | 270 | 13 |
| TRASTUZUMAB | 919 | 2.0% | 66 | 194 | 35 |
| FLUOROURACIL | 837 | 1.6% | 66 | 224 | 37 |
| PEMBROLIZUMAB | 832 | 1.0% | 83 | 361 | 16 |
| DOCETAXEL | 668 | 1.0% | 49 | 187 | 41 |
| PACLITAXEL | 600 | 0.8% | 56 | 133 | 11 |
| NIVOLUMAB | 569 | 0.7% | 35 | 162 | 20 |
| DOXORUBICIN | 530 | 0.6% | 47 | 135 | 30 |
| IRINOTECAN | 477 | 1.7% | 37 | 115 | 8 |
| LEUCOVORIN | 394 | 1.6% | 31 | 96 | 7 |
| AXITINIB | 383 | 2.4% | 27 | 78 | 5 |
| CYCLOPHOSPHAMIDE | 357 | 0.3% | 33 | 99 | 14 |
| TUCATINIB | 355 | 5.9% | 16 | 49 | 0 |