Does ALLOPURINOL Cause Encephalopathy? 79 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 79 reports of Encephalopathy have been filed in association with ALLOPURINOL (Allopurinol). This represents 0.4% of all adverse event reports for ALLOPURINOL.
79
Reports of Encephalopathy with ALLOPURINOL
0.4%
of all ALLOPURINOL reports
26
Deaths
42
Hospitalizations
How Dangerous Is Encephalopathy From ALLOPURINOL?
Of the 79 reports, 26 (32.9%) resulted in death, 42 (53.2%) required hospitalization, and 26 (32.9%) were considered life-threatening.
Is Encephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ALLOPURINOL. However, 79 reports have been filed with the FAERS database.
What Other Side Effects Does ALLOPURINOL Cause?
Drug reaction with eosinophilia and systemic symptoms (2,943)
Acute kidney injury (1,583)
Rash (1,103)
Off label use (921)
Pyrexia (913)
Dyspnoea (905)
Toxic epidermal necrolysis (858)
Pruritus (836)
Diarrhoea (819)
Drug ineffective (780)
What Other Drugs Cause Encephalopathy?
BACLOFEN (845)
METHOTREXATE (775)
ACETAMINOPHEN (608)
IFOSFAMIDE (585)
CYCLOPHOSPHAMIDE (552)
TACROLIMUS (523)
PREDNISONE (489)
DEXAMETHASONE (428)
METFORMIN (418)
ETOPOSIDE (404)
Which ALLOPURINOL Alternatives Have Lower Encephalopathy Risk?
ALLOPURINOL vs ALMOTRIPTAN
ALLOPURINOL vs ALMOTRIPTAN MALATE
ALLOPURINOL vs ALOE VERA LEAF
ALLOPURINOL vs ALOGLIPTIN
ALLOPURINOL vs ALOGLIPTIN\METFORMIN