Does ALLOPURINOL Cause Hepatic failure? 89 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 89 reports of Hepatic failure have been filed in association with ALLOPURINOL (Allopurinol). This represents 0.5% of all adverse event reports for ALLOPURINOL.
89
Reports of Hepatic failure with ALLOPURINOL
0.5%
of all ALLOPURINOL reports
46
Deaths
51
Hospitalizations
How Dangerous Is Hepatic failure From ALLOPURINOL?
Of the 89 reports, 46 (51.7%) resulted in death, 51 (57.3%) required hospitalization, and 9 (10.1%) were considered life-threatening.
Is Hepatic failure Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ALLOPURINOL. However, 89 reports have been filed with the FAERS database.
What Other Side Effects Does ALLOPURINOL Cause?
Drug reaction with eosinophilia and systemic symptoms (2,943)
Acute kidney injury (1,583)
Rash (1,103)
Off label use (921)
Pyrexia (913)
Dyspnoea (905)
Toxic epidermal necrolysis (858)
Pruritus (836)
Diarrhoea (819)
Drug ineffective (780)
What Other Drugs Cause Hepatic failure?
ACETAMINOPHEN (1,392)
RIBAVIRIN (888)
CYCLOPHOSPHAMIDE (629)
METHOTREXATE (598)
BEVACIZUMAB (558)
SOFOSBUVIR (525)
RITUXIMAB (513)
VINCRISTINE (468)
DOXORUBICIN (462)
PREDNISOLONE (425)
Which ALLOPURINOL Alternatives Have Lower Hepatic failure Risk?
ALLOPURINOL vs ALMOTRIPTAN
ALLOPURINOL vs ALMOTRIPTAN MALATE
ALLOPURINOL vs ALOE VERA LEAF
ALLOPURINOL vs ALOGLIPTIN
ALLOPURINOL vs ALOGLIPTIN\METFORMIN