ECULIZUMAB for C3 glomerulopathy: Side Effects & Safety Data
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There are 267 adverse event reports in the FDA FAERS database where ECULIZUMAB was used for C3 glomerulopathy.
Most Reported Side Effects for ECULIZUMAB
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Fatigue | 4,858 | 11.0% | 91 | 944 |
| Off label use | 4,228 | 9.6% | 577 | 658 |
| Haemoglobin decreased | 3,028 | 6.9% | 127 | 1,045 |
| Headache | 2,699 | 6.1% | 56 | 700 |
| Death | 2,221 | 5.0% | 2,221 | 540 |
| Pyrexia | 1,948 | 4.4% | 128 | 1,129 |
| Dyspnoea | 1,819 | 4.1% | 97 | 737 |
| Asthenia | 1,732 | 3.9% | 95 | 627 |
| Drug ineffective | 1,644 | 3.7% | 164 | 472 |
| Nausea | 1,579 | 3.6% | 47 | 516 |
| Malaise | 1,562 | 3.5% | 91 | 591 |
| Platelet count decreased | 1,502 | 3.4% | 111 | 659 |
| Haemolysis | 1,476 | 3.3% | 87 | 557 |
| Hospitalisation | 1,345 | 3.0% | 75 | 1,336 |
| Blood lactate dehydrogenase increased | 1,290 | 2.9% | 79 | 420 |
Other Indications for ECULIZUMAB
Paroxysmal nocturnal haemoglobinuria (12,054)
Haemolytic uraemic syndrome (8,500)
Product used for unknown indication (6,808)
Atypical haemolytic uraemic syndrome (5,848)
Myasthenia gravis (5,715)
Off label use (3,550)
Thrombotic microangiopathy (1,312)
Neuromyelitis optica spectrum disorder (1,097)
Transplant rejection (176)
Antiphospholipid syndrome (126)
Other Drugs Used for C3 glomerulopathy
MYCOPHENOLATE MOFETIL (126)
RAVULIZUMAB-CWVZ (59)
PREDNISONE (46)
PREDNISOLONE (45)
RITUXIMAB (34)
BORTEZOMIB (28)
PEGCETACOPLAN (27)
DEXAMETHASONE (24)
TACROLIMUS (23)
IPTACOPAN (21)