Does FLUOROURACIL Cause Encephalopathy? 239 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 239 reports of Encephalopathy have been filed in association with FLUOROURACIL (FLUOROURACIL). This represents 0.5% of all adverse event reports for FLUOROURACIL.
239
Reports of Encephalopathy with FLUOROURACIL
0.5%
of all FLUOROURACIL reports
19
Deaths
178
Hospitalizations
How Dangerous Is Encephalopathy From FLUOROURACIL?
Of the 239 reports, 19 (7.9%) resulted in death, 178 (74.5%) required hospitalization, and 46 (19.2%) were considered life-threatening.
Is Encephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for FLUOROURACIL. However, 239 reports have been filed with the FAERS database.
What Other Side Effects Does FLUOROURACIL Cause?
Diarrhoea (5,373)
Neutropenia (4,400)
Nausea (3,757)
Vomiting (2,836)
Off label use (2,788)
Neuropathy peripheral (2,605)
Thrombocytopenia (2,426)
Fatigue (2,421)
Disease progression (2,377)
Febrile neutropenia (2,230)
What Other Drugs Cause Encephalopathy?
BACLOFEN (845)
METHOTREXATE (775)
ACETAMINOPHEN (608)
IFOSFAMIDE (585)
CYCLOPHOSPHAMIDE (552)
TACROLIMUS (523)
PREDNISONE (489)
DEXAMETHASONE (428)
METFORMIN (418)
ETOPOSIDE (404)
Which FLUOROURACIL Alternatives Have Lower Encephalopathy Risk?
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOROURACIL\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOXETINE
FLUOROURACIL vs FLUOXETINE\FLUOXETINE