Does IRINOTECAN Cause Hepatic failure? 125 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 125 reports of Hepatic failure have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 0.5% of all adverse event reports for IRINOTECAN.
125
Reports of Hepatic failure with IRINOTECAN
0.5%
of all IRINOTECAN reports
97
Deaths
55
Hospitalizations
How Dangerous Is Hepatic failure From IRINOTECAN?
Of the 125 reports, 97 (77.6%) resulted in death, 55 (44.0%) required hospitalization, and 12 (9.6%) were considered life-threatening.
Is Hepatic failure Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 125 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Hepatic failure?
ACETAMINOPHEN (1,392)
RIBAVIRIN (888)
CYCLOPHOSPHAMIDE (629)
METHOTREXATE (598)
BEVACIZUMAB (558)
SOFOSBUVIR (525)
RITUXIMAB (513)
VINCRISTINE (468)
DOXORUBICIN (462)
PREDNISOLONE (425)
Which IRINOTECAN Alternatives Have Lower Hepatic failure Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE