Does LAMOTRIGINE Cause Necrosis? 34 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 34 reports of Necrosis have been filed in association with LAMOTRIGINE (Lamotrigine ER). This represents 0.1% of all adverse event reports for LAMOTRIGINE.
34
Reports of Necrosis with LAMOTRIGINE
0.1%
of all LAMOTRIGINE reports
1
Deaths
32
Hospitalizations
How Dangerous Is Necrosis From LAMOTRIGINE?
Of the 34 reports, 1 (2.9%) resulted in death, 32 (94.1%) required hospitalization, and 12 (35.3%) were considered life-threatening.
Is Necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LAMOTRIGINE. However, 34 reports have been filed with the FAERS database.
What Other Side Effects Does LAMOTRIGINE Cause?
Drug ineffective (5,175)
Seizure (3,459)
Toxicity to various agents (3,256)
Rash (3,249)
Foetal exposure during pregnancy (2,985)
Off label use (2,625)
Completed suicide (2,433)
Drug reaction with eosinophilia and systemic symptoms (2,235)
Dizziness (2,170)
Pyrexia (1,967)
What Other Drugs Cause Necrosis?
METHOTREXATE (155)
PREDNISONE (143)
TACROLIMUS (120)
ADALIMUMAB (119)
MYCOPHENOLATE MOFETIL (101)
CYCLOPHOSPHAMIDE (97)
RITUXIMAB (97)
GLATIRAMER (84)
PREDNISOLONE (83)
METHYLPREDNISOLONE (76)
Which LAMOTRIGINE Alternatives Have Lower Necrosis Risk?
LAMOTRIGINE vs LANADELUMAB
LAMOTRIGINE vs LANADELUMAB-FLYO
LAMOTRIGINE vs LANREOTIDE
LAMOTRIGINE vs LANSOPRAZOLE
LAMOTRIGINE vs LANTHANUM