Does METHOTREXATE Cause Necrosis? 155 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 155 reports of Necrosis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
155
Reports of Necrosis with METHOTREXATE
0.1%
of all METHOTREXATE reports
23
Deaths
96
Hospitalizations
How Dangerous Is Necrosis From METHOTREXATE?
Of the 155 reports, 23 (14.8%) resulted in death, 96 (61.9%) required hospitalization, and 13 (8.4%) were considered life-threatening.
Is Necrosis Listed in the Official Label?
Yes, Necrosis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Necrosis?
PREDNISONE (143)
TACROLIMUS (120)
ADALIMUMAB (119)
MYCOPHENOLATE MOFETIL (101)
CYCLOPHOSPHAMIDE (97)
RITUXIMAB (97)
GLATIRAMER (84)
PREDNISOLONE (83)
METHYLPREDNISOLONE (76)
DEXAMETHASONE (74)
Which METHOTREXATE Alternatives Have Lower Necrosis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA