Necrosis: Which Medications Cause It? (3,402 Reports Across 323 Drugs)
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Necrosis has been reported as an adverse event with 323 different drugs in the FDA's FAERS database, with 3,402 total reports. 483 of these reports resulted in death.The drugs most commonly associated with Necrosis are METHOTREXATE, PREDNISONE, and TACROLIMUS.
3,402
Total Reports
323
Drugs Involved
483
Deaths
1,709
Hospitalizations
54.5 yrs
Average Patient Age
53.0% / 47.0%
Female / Male
Which Drugs Cause Necrosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 155 | 0.1% | 23 | 96 | 13 |
| PREDNISONE | 143 | 0.1% | 32 | 88 | 12 |
| TACROLIMUS | 120 | 0.1% | 43 | 85 | 19 |
| ADALIMUMAB | 119 | 0.0% | 5 | 60 | 3 |
| MYCOPHENOLATE MOFETIL | 101 | 0.1% | 28 | 61 | 6 |
| CYCLOPHOSPHAMIDE | 97 | 0.1% | 20 | 54 | 13 |
| RITUXIMAB | 97 | 0.1% | 18 | 54 | 5 |
| GLATIRAMER | 84 | 0.2% | 0 | 9 | 1 |
| PREDNISOLONE | 83 | 0.1% | 16 | 59 | 9 |
| METHYLPREDNISOLONE | 76 | 0.1% | 20 | 44 | 9 |
| DEXAMETHASONE | 74 | 0.1% | 19 | 54 | 16 |
| CISPLATIN | 72 | 0.2% | 12 | 22 | 2 |
| CANAGLIFLOZIN | 71 | 0.3% | 0 | 56 | 4 |
| DOXORUBICIN | 67 | 0.1% | 6 | 27 | 3 |
| BEVACIZUMAB | 65 | 0.1% | 15 | 22 | 4 |
| VINCRISTINE | 57 | 0.1% | 9 | 31 | 2 |
| CARBOPLATIN | 54 | 0.1% | 9 | 30 | 0 |
| DENOSUMAB | 51 | 0.0% | 0 | 13 | 0 |
| NIVOLUMAB | 49 | 0.1% | 5 | 30 | 4 |
| PEMBROLIZUMAB | 49 | 0.1% | 14 | 21 | 3 |