Does METFORMIN Cause Hepatic cytolysis? 175 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 175 reports of Hepatic cytolysis have been filed in association with METFORMIN (Metformin Hydrochloride). This represents 0.2% of all adverse event reports for METFORMIN.
175
Reports of Hepatic cytolysis with METFORMIN
0.2%
of all METFORMIN reports
59
Deaths
134
Hospitalizations
How Dangerous Is Hepatic cytolysis From METFORMIN?
Of the 175 reports, 59 (33.7%) resulted in death, 134 (76.6%) required hospitalization, and 27 (15.4%) were considered life-threatening.
Is Hepatic cytolysis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METFORMIN. However, 175 reports have been filed with the FAERS database.
What Other Side Effects Does METFORMIN Cause?
Lactic acidosis (16,316)
Acute kidney injury (11,361)
Diarrhoea (7,679)
Toxicity to various agents (5,669)
Metabolic acidosis (5,236)
Hypoglycaemia (5,047)
Drug ineffective (4,991)
Nausea (4,915)
Vomiting (4,624)
Blood glucose increased (4,038)
What Other Drugs Cause Hepatic cytolysis?
ACETAMINOPHEN (1,469)
ATORVASTATIN (681)
PEMBROLIZUMAB (601)
CARBOPLATIN (577)
METHOTREXATE (468)
SULFAMETHOXAZOLE\TRIMETHOPRIM (356)
PACLITAXEL (324)
ENOXAPARIN (307)
AMOXICILLIN (273)
VALACYCLOVIR (261)
Which METFORMIN Alternatives Have Lower Hepatic cytolysis Risk?
METFORMIN vs METFORMIN\PIOGLITAZONE
METFORMIN vs METFORMIN\ROSIGLITAZONE
METFORMIN vs METFORMIN\SAXAGLIPTIN
METFORMIN vs METFORMIN\SITAGLIPTIN
METFORMIN vs METFORMIN\VILDAGLIPTIN