Hepatic cytolysis: Which Medications Cause It? (10,164 Reports Across 626 Drugs)
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Hepatic cytolysis has been reported as an adverse event with 626 different drugs in the FDA's FAERS database, with 10,164 total reports. 361 of these reports resulted in death.The drugs most commonly associated with Hepatic cytolysis are ACETAMINOPHEN, ATORVASTATIN, and PEMBROLIZUMAB.
10,164
Total Reports
626
Drugs Involved
361
Deaths
5,408
Hospitalizations
54.9 yrs
Average Patient Age
57.2% / 42.8%
Female / Male
Which Drugs Cause Hepatic cytolysis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 1,469 | 1.1% | 37 | 1,019 | 122 |
| ATORVASTATIN | 681 | 0.9% | 3 | 388 | 14 |
| PEMBROLIZUMAB | 601 | 0.7% | 30 | 311 | 21 |
| CARBOPLATIN | 577 | 0.7% | 17 | 254 | 7 |
| METHOTREXATE | 468 | 0.2% | 8 | 180 | 26 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 356 | 0.9% | 4 | 234 | 28 |
| PACLITAXEL | 324 | 0.4% | 21 | 155 | 11 |
| ENOXAPARIN | 307 | 1.2% | 5 | 165 | 3 |
| AMOXICILLIN | 273 | 0.9% | 2 | 149 | 3 |
| VALACYCLOVIR | 261 | 2.0% | 3 | 156 | 12 |
| PEMETREXED | 252 | 1.1% | 16 | 119 | 4 |
| LANSOPRAZOLE | 246 | 0.4% | 0 | 137 | 1 |
| QUETIAPINE | 245 | 0.3% | 54 | 136 | 26 |
| NIVOLUMAB | 241 | 0.3% | 11 | 126 | 8 |
| PANTOPRAZOLE | 235 | 0.3% | 0 | 126 | 18 |
| RITUXIMAB | 222 | 0.1% | 3 | 120 | 15 |
| PIPERACILLIN\TAZOBACTAM | 213 | 1.1% | 3 | 134 | 1 |
| LEVOFLOXACIN | 202 | 0.5% | 2 | 135 | 16 |
| AMOXICILLIN\CLAVULANATE | 200 | 1.3% | 0 | 114 | 13 |
| DEXAMETHASONE | 200 | 0.2% | 8 | 88 | 8 |