Does METHOTREXATE Cause Hepatic cytolysis? 468 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 468 reports of Hepatic cytolysis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
468
Reports of Hepatic cytolysis with METHOTREXATE
0.2%
of all METHOTREXATE reports
8
Deaths
180
Hospitalizations
How Dangerous Is Hepatic cytolysis From METHOTREXATE?
Of the 468 reports, 8 (1.7%) resulted in death, 180 (38.5%) required hospitalization, and 26 (5.6%) were considered life-threatening.
Is Hepatic cytolysis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 468 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatic cytolysis?
ACETAMINOPHEN (1,469)
ATORVASTATIN (681)
PEMBROLIZUMAB (601)
CARBOPLATIN (577)
SULFAMETHOXAZOLE\TRIMETHOPRIM (356)
PACLITAXEL (324)
ENOXAPARIN (307)
AMOXICILLIN (273)
VALACYCLOVIR (261)
PEMETREXED (252)
Which METHOTREXATE Alternatives Have Lower Hepatic cytolysis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA