Does PYRAZINAMIDE Cause Cholestasis? 39 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 39 reports of Cholestasis have been filed in association with PYRAZINAMIDE (Pyrazinamide). This represents 0.7% of all adverse event reports for PYRAZINAMIDE.
39
Reports of Cholestasis with PYRAZINAMIDE
0.7%
of all PYRAZINAMIDE reports
3
Deaths
27
Hospitalizations
How Dangerous Is Cholestasis From PYRAZINAMIDE?
Of the 39 reports, 3 (7.7%) resulted in death, 27 (69.2%) required hospitalization, and 6 (15.4%) were considered life-threatening.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PYRAZINAMIDE. However, 39 reports have been filed with the FAERS database.
What Other Side Effects Does PYRAZINAMIDE Cause?
Drug-induced liver injury (588)
Drug reaction with eosinophilia and systemic symptoms (492)
Paradoxical drug reaction (407)
Vomiting (307)
Pyrexia (301)
Drug ineffective (298)
Off label use (288)
Hepatotoxicity (279)
Drug resistance (269)
Nausea (251)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which PYRAZINAMIDE Alternatives Have Lower Cholestasis Risk?
PYRAZINAMIDE vs PYRIDOSTIGMINE
PYRAZINAMIDE vs PYRIDOXINE
PYRAZINAMIDE vs PYRIDOXINE\THIAMINE
PYRAZINAMIDE vs PYRIMETHAMINE
PYRAZINAMIDE vs PYROTINIB