Does PYRAZINAMIDE Cause Hepatotoxicity? 279 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 279 reports of Hepatotoxicity have been filed in association with PYRAZINAMIDE (Pyrazinamide). This represents 5.1% of all adverse event reports for PYRAZINAMIDE.
279
Reports of Hepatotoxicity with PYRAZINAMIDE
5.1%
of all PYRAZINAMIDE reports
59
Deaths
94
Hospitalizations
How Dangerous Is Hepatotoxicity From PYRAZINAMIDE?
Of the 279 reports, 59 (21.1%) resulted in death, 94 (33.7%) required hospitalization, and 18 (6.5%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for PYRAZINAMIDE.
What Other Side Effects Does PYRAZINAMIDE Cause?
Drug-induced liver injury (588)
Drug reaction with eosinophilia and systemic symptoms (492)
Paradoxical drug reaction (407)
Vomiting (307)
Pyrexia (301)
Drug ineffective (298)
Off label use (288)
Drug resistance (269)
Nausea (251)
Anaemia (234)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which PYRAZINAMIDE Alternatives Have Lower Hepatotoxicity Risk?
PYRAZINAMIDE vs PYRIDOSTIGMINE
PYRAZINAMIDE vs PYRIDOXINE
PYRAZINAMIDE vs PYRIDOXINE\THIAMINE
PYRAZINAMIDE vs PYRIMETHAMINE
PYRAZINAMIDE vs PYROTINIB