Does METHOTREXATE Cause Hepatotoxicity? 1,917 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 1,917 reports of Hepatotoxicity have been filed in association with METHOTREXATE (Methotrexate). This represents 0.8% of all adverse event reports for METHOTREXATE.
1,917
Reports of Hepatotoxicity with METHOTREXATE
0.8%
of all METHOTREXATE reports
130
Deaths
489
Hospitalizations
How Dangerous Is Hepatotoxicity From METHOTREXATE?
Of the 1,917 reports, 130 (6.8%) resulted in death, 489 (25.5%) required hospitalization, and 133 (6.9%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatotoxicity?
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
RIBOCICLIB (585)
Which METHOTREXATE Alternatives Have Lower Hepatotoxicity Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA